Managing and validating laboratory information systems


13-Nov-2019 07:34

managing and validating laboratory information systems-45

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Patients with documented lithium levels (≥ 2 detectable measurements) were categorized as the lithium-exposed group (n = 2795), and all other patients of the same sex and age group without lithium measurements were considered non-exposed controls (n = 689 228).Cox proportional hazards analyses were performed and adjusted for age ( 0.6 m Eq/L) were associated with stage three chronic kidney disease (HR 1.62; 95% CI 1.41–1.85), hypothyroidism (HR 1.62; 95% CI 1.35–1.94), hyperthyroidism (HR 1.88; 95% CI 1.33–2.66) high total serum calcium (HR 1.54; 95% CI 1.22–1.95) and high adjusted serum calcium concentrations (HR 2.05; 95% CI 1.54–2.72).The study results indicated that the younger women subgroup and patients with high serum lithium concentrations were more likely to develop lithium-induced hypothyroidism and chronic kidney disease.The older women subgroup was more likely to develop lithium-induced high total serum calcium (HR 1.92; 95% CI 1.58–2.33) and high adjusted serum calcium concentrations (HR 1.39; 95% CI 1.13–1.71) = 953).When the requested test is used for patient care, it is managed and funded by DLM, but when used primarily for research DLM only assists the researchers in finding an appropriate testing site.

managing and validating laboratory information systems-46

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A major issue is what tests should be offered in the regular test menu.

All lithium patients registered from 1980 to 2012 at an Italian clinic were screened for enrollment, and estimated glomerular filtration rate (e GFR) was calculated from serum creatinine concentration using the MDRD Study Group equation.



Apr 8, 2005. ASTM E 2006-00 „Standard Guide for Validation of Laboratory Information Management Systems“. And a lot more… continue reading »


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Ades, the use of Laboratory Information Management Systems LIMS has revo-. Currently, detailed guidance regarding system validation of LIMS is not avail-.… continue reading »


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